Presumably they have unused compute in those hours and figure they may as well enable people to use it and get more invested into their ecosystem.
What I wish Anthropic would do is be a lot more explicit about what windows apply when. Surely they have the data to say "you get X usage from hours A to B, Y usage from B to C"
>Vaccinated individuals were older than unvaccinated individuals (mean [SD] age, 38.0 [11.8] years vs 37.1 [11.4] years), more frequently women (11 688 603 [51.3%] vs 2 876 039 [48.5%]) and had more cardiometabolic comorbidities (2 126 250 [9.3%] vs 464 596 [7.8%]).
This is interesting because of "supposed" cardiovascular effects of the vaccine that many folks were worried about. Even more confounding is the gender differences. You'd think skewing women would skew away from cardiovascular issues.
An alternate interpretation is that the at risk cardio unvaccinated died of COVID for some reason.
The increase in myocarditis from the vaccine is well-documented. (And very small.)
COVID causes myocarditis too (even for young people unlikely to die from COVID itself), at much higher rates. So you only need a 20% chance of contracting COVID for the vaccine to be net positive in the least obviously positive age group.
I am not a physician, but I expect that decades hence we will see the health effects of repeated Covid infections. I'm guessing specifically around cardio health and dementia risk.
Your cite reads to me like a statement on the available data, which is interesting in its own ways but can be corrected for when it's irrelevant to the hypothesis.
>Government actions that restrict the ability to privately own or make use of computational resources for lawful purposes, which infringes on citizens' fundamental rights to property and free expression, must be limited to those demonstrably necessary and narrowly tailored to fulfill a compelling government interest in public health or safety.
Exactly. I was hoping that this law would be the pushback to the overzealous prosecution of DeCSS, people who defeat DRM locks in order to lawfully back up the multimedia data that they already paid for, etc.
I also wonder what the impact of the law is on TPM chips on computers (restricting your ability to boot whatever OS you want), the locked-down iOS mobile app store, etc.
I admit I'm not knowledgeable about this law but as it's written it seems fairly meaningless to me, as it could be interpreted in many different ways, and the exclusion is a hole you could drive a metaphorical truck through.
I work in drug discovery (like for real, I have a DC under my belt, not hypothetical AI protein generation blah blah) and had the opposite experience reading it. We understand so little about most drugs. Dialing out selectivity for a closely related protein was one of the most fun and eye opening experiences of my career.
Of course we've thought of all these things. But it's typically fragmented, and oftentimes out of scope. One of the hardest parts of any R&D project is honestly just doing a literature search to the point of exhaustion.
I side with you. The more you know, the more you discover what you don’t know.
Every attempt to consider the extremely complex dynamics of human biology as a pure state machine, like with Pascal, deterministic of your know all the factors, is simplification and can safely be rejected as hypotheses.
Hormons, age, sex, weight, food, aging, sun, environmental, epigenetic changes, body composition, activity level, infections, medication all play a role, even galenic.
Put it this way: even in Pascal (especially in Pascal) you generally work in source code. You don't try to read the object code, and if you do, you generally might try to decompile or disassemble it. What you don't do -unless you're desperate- is try to understand what the program is doing by means of directly reading the hexdump (let alone actually printing it out in binary!)
Now imagine someone has written a Compiler that compiles something much more sophisticated into Pascal (some 'fourth generation language' (4GL) ) . Now you'd be working in that 4GL, not in Pascal. Looking at the Pascal source code here would be less useful. Best to look at the 4GL code.
Biology is a bit like that. It's technically deterministic all the way down (until we reach quantum effects, at least). But trying to explain why Aunt Betty sneezed by looking at the orbital hybridization state of carbon atoms might be a wee bit unuseful at times. Better to just hand her a handkerchief.
(And even this rule has exceptions: Abstractions can be leaky!)
Are there any new developments on the technical side of microscopy such as new materials or techniques? What journals or trade papers are reliable in researching this information?
How does one become a microscopist as a profession? It seems like a specialized field with a narrow entry point and a lot of hoops.
On the technical side, yes. The biggest new developments I can quickly think of are:
1) Cold field emission guns. The big challenge of an electron source is producing a coherent beam - that is a beam that comes off the tip one electron at a time, at the same location, the same angle, and with the same energy. The cooler the tip runs, the more coherent it tends to be. This has made a big difference and is just now widely commercially available.
2) Narrow pole-piece gap. The sample on most TEMs sits sandwiched between two objective lenses that operate in tandem - these are typically called twin objectives. The upper one ensures the beam is parallel, which primarily results in uniform defocus (or focus if one so desires) across the image. The lower one is responsible for image formation and initial magnification (actually, all of your resolution essentially). The gap between them is responsible for your primary aberrations: spherical and chromatic. Reducing this gap reduces the total aberrations in the image.
I will side bar that the physics of a microscope are not really holding it back from what I'm doing - generating structures of biomolecules. Really, I'm more limited by the camera technology than anything, because the cameras simply aren't performant enough to dose the images to the level I'd like, to collect as many images as possible in as short a time as possible. Fundamentally, I tend to be limited by number of observations.
For the really cutting edge stuff...check out ptychography:
>How does one become a microscopist as a profession? It seems like a specialized field with a narrow entry point and a lot of hoops.
There are basically two routes for TEM - material science, or biochemistry. The way to become a microscopist for me was to show up at a University that had a grant for a microscope, but no one to operate it. :)
In general, universities operate TEM cores, frequently called bioimaging or something. (Structural biology if it's newer although that's just one application among many). Frequently there are positions for all education levels - bachelor's through PhD, depending on what one wants to do. Training is a mix of hands on (interfacing with complicated systems) and theoretical (physics and image formation). Typically the operators aren't the most theoretical, but have a lot of very niche practical knowledge you only get from being around broken microscopes.
A lot of replies that are mostly true, or somewhat true, or simply missing the real reasons.
There are two factors here:
1) Vaccine-derived immunity is a function of the individual's immune response, which in general, weakens significantly with age. It is not unrealistic for a vaccine to simply fail to elicit any response in someone old enough.
2) It is very, very difficult to recruit folks without HPV that are over 40 for a clinical trial. Most people of that age, who were never immunized, most likely have had it. This significantly convolutes the signal.
3) This is all especially confounded once something becomes "standard of care". Every year there are fewer and fewer people age 40+ with HPV.
For these reasons, the vaccine is currently officially ??? in people over 40. Most doctors will prescribe it anyways if you ask. It may or may not infer immunity. It almost certainly will not harm you.
I can confirm that this phone is perfect for it. Everything is there and usable if you truly need it, but I cannot wait to put the phone back in my pocket because of unpleasant it is to use.
I am a structural biologist working in pharmaceutical design and this type of thing could be wildly useful (if it works).
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