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The Regeneron press release mentions that the therapy includes a hair cell specific regulator for the gene:

https://investor.regeneron.com/news-releases/news-release-de...

That of course doesn't rule out problems, but the treatment doesn't naively turn on the protein production either.


What do you want most to mean here?

The ~750 pngs are about 15 megabytes. The 77 photographic images are 22 megabytes.

Somewhat a death of 1000 cuts.

I used https://www.xpdfreader.com/pdfimages-man.html to extract them and take a look.


Thanks for that. At first glance, it looks like that is a good place to be, regarding images. I will still investigate when I find time.

Probably the main thing you could look at is what pixel density you want in your images.

For example, there's a 1 megabyte image of a tanker trailer that is displayed at about 1.5 x 3 inches, you could get rid of 3/4 of those pixels (going from ~400 ppi to ~200 ppi) and not really change the quality of the image for a casual reader.


that’s a really good place to start, thank you!

It's expensive. A relative has one in the northern Great Lakes, they wouldn't have installed it if their house had access to natural gas.

Our house came with one and we upgraded the unit a few years ago. It's very efficient in terms of units of energy consumed, but in my area of the world gas is significantly cheaper than electricity so it ends up being expensive to run.

That said, we will install solar at some point and then it'll be "free" HVAC.


How do we make those markets more competitive?

Services are expensive because they compete for labor with other things.

I think US grocery prices are higher because there's not really a goal of keeping them lower. Subsidies could be structured to ensure that they help the consumer, but they aren't. And so on.


Grocery stores don't make any money though. That's why its practically a huge monopoly, and even still they hardly make money. Food in general is an awful business to be in.

Food is expensive and no one is getting rich from it. It's a strong sign you are in an advanced economy, and will be having it hard if you aren't part of that "advanced".


Sure, but we subsidize farmers and then they sell their products to middlemen and we are like "yeah whatever you want".

Attach the subsidy to the eventual retail price and they would at least be a little lower.


This is a silly inversion of causality. The thing that causes increased economic activity is people working for it. Not just the wealthy with their vast resources, the many people that work alongside them because they think it will be beneficial.

> Not just the wealthy

I think you misread. I literally used myself as an example and am definitely not that wealthy :p

> because they think it will be beneficial

The Capital-class have, on the other hand, definitely constructed a world where this is true for us as individual. However I am talking about the effect on Us the collective-singular.


Meh, it's not strictly commutative, and money is ultimately an abstraction for real resources, not just an abstraction.

Really, if you didn't have a job you'd be working much harder for less. The vibes say that's bullshit, but whatever.


Staying as healthy as you can is the best strategy with perfect healthcare too.

Yeah, it's the people that think solar is relatively clean and has become cheap that are the problem, not the people that never grew out of oppositional defiance disorder.

It depends a little bit on how many bang bangs the boom boom has.

You fire all your missiles then.. you turn around and leave. The enemy isn't in range to engage you, you're flying away at least the same speed they're chasing, what are they going to do?

The enemy isn't in range to engage you

That's convenient. Hopefully they don't use their massive numerical advantage in some sort of scheme to make it not true.


What are they going to do, fly over and bomb washington??

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