This is what happened to my grandmother. She had had a hard life full of catastrophes (20+ of her relatives died in Auschwitz and Dachau), being stifled (grandfather forbid her to take a job), and resulting depression and alcoholism. She had had an essential tremor for 20 years, but apart from that, she was fine according to doctors. She told anybody she‘d just did not want to continue anymore. She developed a sore area of skin on her foot which eventually landed her in hospital, lost almost all her weight, and never returned home.

She never talked about the cruelties she and her family had to endure from the Nazis. And in the end, she didn’t seem to even remember. It was simply too much for her to ever cope.

Just an n=1, but personally I am convinced that you can die from giving up (or a broken heart, on another matter).