True, but also the other way around: A less advanced civilization would have much more trouble with elephants, sea urchins, bacteria, and other natural factors than with humans.
Stepping on a sea urchin is no beuno. I remember one time snorkelling and I was being pulled by a rip tide and I was like no big deal, I can just slowly head a different direction until I started being pulled barely past sea urchins on corals and then I was freaked out. They are dastardly.