They lost a B-2 bomber because of moisture in a sensor. ($1.4 billion - oops). https://en.wikipedia.org/wiki/2008_Andersen_Air_Force_Base_B...

And a 757 that was thought to have crashed due to pilot confusion, caused by instrument error, ultimately because the pitot tube covers were left off and the hole is just about the size a mud dauber likes. https://en.m.wikipedia.org/wiki/Birgenair_Flight_301