What comment systems are you thinking about? With Disqus the rest of the page shouldn't really matter at all, whether it's dynamic, cached, static etc…
Depending on one's error tolerance, maybe dynamic configuration would help (check if you're hit heavily and/or check if you're on HN/slashdot/reddit, then modify the config accordingly).
Depending on one's error tolerance, maybe dynamic configuration would help (check if you're hit heavily and/or check if you're on HN/slashdot/reddit, then modify the config accordingly).