People have been using Ketamine for decades and the bladder damage didn't seem to start until a couple years ago, so it's possibly not due to ketamine itself.
I know people on the London party scene who got these symptoms over ten years ago. I suspect that it wasn't until there was a culture of people taking large daily doses that this issue became prevalent, as it would be unlikely for this to happen either medically, or among those who were taking this as an occasional psychedelic. It takes chronic long term exposure for these symptoms to occur.
